Recurring fever in adults

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Autoinflammatory diseases are caused by inflammasome dysregulation leading to overproduction of proinflammatory cytokines and a pathological delay in the inflammation switching off. The progress of cellular biology has partially clarified pathogenic mechanisms behind monogenic autoinflammatory diseases, whereas little is known about the polygenic ones. PFAPA syndrome has a typical inception in the pediatric age, but a delayed onset during adulthood has been described as well. Treatments required as well as effectiveness of tonsillectomy remain controversial, even if the disease seems to have a self-limited course mostly in children. By definition autoinflammatory diseases AIDs are characterized by recurrent episodes of inflammation in the absence of autoreactive T-cells and autoantibodies [ 1 ]. From the understanding that the so-called monogenic periodic fevers are the prototype of pure AIDs, our knowledge has now expanded to encompass multifactorial and polygenic diseases among AIDs [ 2 , 3 ].
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How to Tell When a Fever in Adults Is Serious

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Periodic Fever Syndromes - Cancer Therapy Advisor

Periodic fever syndromes refer to diseases that cause periodic episodic fever that do not have an infectious virus, bacteria cause. In general, children with these syndromes are well between episodes. Many of these syndromes are hereditary passed down from parents and result from a mutation defect or mistake in a gene this is the code that determines the structure of our proteins. The syndromes are defined by several factors, including:. Many of these syndromes have a specific treatment, often based on understanding the problem caused by the genetic defect. Familial Mediterranean fever FMF is the most common periodic fever syndrome. Patients suffer from recurrent episodes of fever, accompanied by abdominal, chest and joint pain, and swelling.
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How to Recognize, Diagnose Periodic Fever Syndromes in Adults

A number of autoinflammatory syndromes that result from genetic mutations have been described recently. The vast majority occur in children. However, three periodic fever syndromes are important for rheumatologists who treat adults to know about. The goal of this review is to provide a concise description of each condition, and to help the clinician understand when to suspect one and how to diagnose it.
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Autoinflammatory diseases, also commonly known as periodic fever syndromes, are systemic inflammatory diseases caused by malfunctions of the innate immune system. Most autoinflammatory diseases are genetic and the first symptoms start in childhood, but most are chronic lifelong diseases. However, due to the complex range of symptoms and their rarity, patients with these conditions may not get diagnosed or helpful treatment until they are adults.
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